​​​giving men a better chance of beating prostate cancer 

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Embryonic Gene Targeting

Dr Richard Morgan


 

HOX

Potential targets for novel therapies include proteins involved in cell growth and signalling within the cell. These include proteins, so called transcription factors, that have previously been identified as being switched on in cancer and therefore lead to unchecked growth of cells. Of particular note are the HOX genes, a family of proteins normally involved in development of the nervous system in the embryo. We have designed a small protein, HXR9, which is able to pass into the cell and disrupt the interaction between HOX and a second protein, PBX This protein is able to cause cell death when added to cancer cells in culture and also can also reduce or prevent the growth of melanoma, breast, lung, ovarian and prostate tumours. We hope to develop this protein further for use as a therapy for cancer.